Last year, Hangzhou strictly controlled dogs, all dogs must be vaccinated, and various adverse reactions due to vaccines followed one after another. In fact, this phenomenon is quite common, but the severity It varies, ranging from itching, vomiting, diarrhea, to elevated body temperature, difficulty urinating, shortness of breath and even death from shock.

In order to avoid this phenomenon from happening again, let's learn about vaccine allergy first.

Occurs within 2 minutes after the dog is vaccinated Allergic reaction. In the early stage of shock, the dog will be particularly excited and restless, the heart rate is fast, the heart rate is 70-160 beats/min, and the breathing rate increases to 30 beats/min. When the body temperature rises to 39.8-41.0 ℃, the mucous membranes cyanosis (referring to the increase of deoxyhemoglobin in the blood makes the skin and mucous membranes turn blue and purple), which will last for about 10-15 minutes.

Immediately afterwards, the dog gradually changed from being excited to depression, with bradycardia and weakness, arrhythmia, thin and weak pulse, pale mucous membranes, cold limbs, muscle relaxation and weakness, and capillary filling Prolonged time, difficulty breathing, thirst, unresponsiveness, complete disappearance of pain, visual, and auditory stimuli, dilated pupils, decreased blood pressure, and finally coma and death.

Occurs 15-20 minutes after the dog is vaccinated, the dog will experience cramping abdominal pain, emotional irritability, persistent moaning, abdominal muscles There is a feeling of twitching. When you touch the dog's lower abdomen with the palm plane, there will be a feeling of intestinal peristalsis and rolling.

Occurs on day 2 after the dog is vaccinated, the dog begins to have diarrhea, decreased urination, thirst, decreased appetite (or refuses to eating), inability to walk.

Occurs on the 2nd day after the dog is vaccinated, with fever, skin redness, and high body temperature (about 39.8℃)(.

Usually 3-6 days after the injection, the dog's ears, lower abdomen and back will show symptoms of urticaria.

· The blood pressure was measured, and the changes in the initial shock were not obvious. The blood pressure decreased during the shock period. For example, when the blood pressure was lower than 6666Pa, the animal's consciousness disappeared; if it continued to decrease When the temperature reached 4666Pa, the animal fell into a coma for 2 hours, and finally died.

· Heart rate/pulse rate monitoring, the heart rate is fast, generally reaching 160 beats/min.

· Central venous pressure measurement , except for cardiogenic shock. During the period of shock in dogs, the central venous pressure is generally lower than the normal value of 0-5cm water column.

·Measurement of cardiac output, cardiac output decreased.

·Measurement of Po2, and partial pressure of oxygen also decreased.

·Measurement of capillary filling, gently press the gum with finger Or the edge of the tongue, observe the blood flow filling time after decompression, when the dog is in shock, the capillary filling time exceeds the normal value of 1 second.

is the most serious hypersensitivity reaction, according to the symptoms mentioned above, symptomatic treatment. If the rescue is not timely, it will lead to death.

· Oxygen for treatment. The shock dog must ensure that there are enough Ventilation, maintain oxygen tension, and make the airway unobstructed. Quickly insert the oxygen bag tube into the dog's nasal cavity, and use positive pressure ventilation until the dog breathes normally;

· Drug treatment. Epinephrine hydrochloride 0.1 -0.5mL, intramuscular injection (according to the dog's weight and The severity of the reaction symptoms, the dose can be adjusted as appropriate);

· 0.9% saline 250mL, chlorpheniramine 1mL intravenous drip;

· 0.5% atropine sulfate, intramuscularly at 0.2 mL per kilogram body weight;

· intramuscular injection of 0.5—1.0 mL/puppy (dosage for puppies can be adjusted as appropriate);

· Gentamicin 80,000-100,000 U/dog, intramuscularly (dosage for puppies can be adjusted as appropriate);

· Cannkang treatment solution 4mL, intramuscular injection (dosage for puppies can be adjusted as appropriate);

250mL of 0.9% normal saline, 250mL of 5% glucose, and 2mL of hemostatic if there is bloody stool, intravenously, 1 per day times for 3 days;

· 10% aminopyrine 2-4mL, intramuscularly, puppies can use 30% analpine nearly 1mL drop Nasal;

· Vitamin C 2-4mL, intramuscularly (the dose for puppies can be adjusted as appropriate);

Dermatitis mainly Itching on the ears and abdomen, hives on the back.

· Oxycortisone, 1-2 mL per dog, intramuscularly for 3 days (the dose for puppies can be adjusted as appropriate);

· Chlorpheniramine injection 1-2 mL /Only, intramuscularly;

· Hydrocortisone ointment, apply to the affected area;

· Synergy Dosage of Canine Wulian Attenuated Vaccine: 1 dose per bottle of vaccine, dissolved in 2 mL of water for injection before use; The appropriate interval is 2-3 weeks; ②Adult dogs should be injected twice a year in a row, and the injection interval should be 2-3 weeks; ③The injection method should be subcutaneous or intramuscular;

· Canine pentavalent vaccine It is a vaccine for dogs, with strong specificity to dogs and good immune effect, but it is only used for preventive injections of confirmed healthy dogs; ;

· It is strictly forbidden to give dogs with latent infection;

· For dogs with polyvalent serum, rabies vaccine should be vaccinated after 2-3 weeks;

· pets during rabies vaccination , do not feed with frozen and spicy food, do not exercise vigorously, do not get in the rain, do not shower within 6 days, keep warm in winter, try to avoid the above stress reactions