Chondrodysplasia in the breed of the breed is caused by an autosomal dominant gene (Fd), and Takanosu et al. A fully dominant gene, that is, a trait in which the dominant gene does not completely obscure the expression of the other gene in the allele. Fold cat gene defect is a hereditary bone disease that cannot be cured, and most of the conditions will continue to deteriorate and cannot be cured. And the only way to avoid this genetic disease is to give up breeding fold cats.

Fold cat gene defect

1. The fold cat is a genetic disease caused by a dominant gene on an autosomal chromosome. It is now believed that This is actually an incomplete dominant gene. All Scottish Fold cats who are homozygous for the fold gene have two genetic variants (Fd/Fd) and are severely affected. All Scottish Fold cats who are heterozygous for the fold gene have a mutated genetic gene (Fd/fd), and they also develop the disease, but the disease is usually milder.

2. Chondrodysplasia of fold cat with homozygous Fd/Fd gene, in the study of gene homozygous fold cat, the most consistent finding is abnormally stubby tail with stiff root . The reason for this is that the coccyx is unusually short and wide, and the growths are fused together. The folded cat's limbs are also deformed, and the feet are relatively short. The metatarsal and metacarpal bones, the bones between the wrist, ankle, and toes, and the phalanges also deform and widen, but to a lesser extent. Over time, the joints at the ends of the extremities will suffer from disease and osteoarthritis. There will be bone growth around these joints, commonly known as exostoses, which will make joint inflammation more serious and eventually lead to joint fusion.

Early symptoms of fold cat gene defect:

1. The fold cat's tail is stubby, stiff and unable to flex. Some sick cats cannot swing their tails.

2. The hind limbs of the folded cat are too short, with unusual bends, growths or lumps.

3. The limbs and joints of the folded cat are swollen.

4. The hind paws of the folded cat are abnormally thick. If you observe carefully, when the cat sits upright, the pillow flesh of the hind paws cannot touch the ground.

5. The nails of the fold cat grow abnormally.

6. Similar symptoms can also occur in the front limbs of the folded cat, but the emotion is higher than that of the hind limbs, which is actually caused by the stiffness of their hind limbs, or the pain when flexing.

The onset period of gene defect in fold cats:

Fold cats are born with a hereditary skeletal disease, that is, chondro-ossification dysplasia. All fold cats with the fold gene have the chance to develop some degree of bone and joint disease. This is a typical genetic disease of the folded cat, with bone hyperplasia first, followed by bone spurs, and finally paralysis. The onset period ranges from 2 months to 6 months of age, but in some cases it begins after 1 year of age. There is no cure for this hereditary bone disease, and most of the conditions will continue to deteriorate and cannot be cured. And the only way to avoid this genetic disease is to give up breeding fold cats.