The African tree snake can kill people. Because the African tree snake is a very ferocious reptile, the venom of the African tree snake is very venomous enough to kill an adult. The African tree snake occupies ninth place on Nigel Marvin's list of the top ten deadliest venomous snakes in South Africa.

The African tree snake has long venomous fangs at the back of the mouth, extending straight to the front of the mouth. After being bitten by the venomous teeth of the African tree snake, the blood will not coagulate, the body will bleed from the seven orifices, and the internal organs will also bleed profusely. The death process is slow and painful, and only anti-venom can save the life of the injured.