The Burmese python is thick and stout, with a large head and a small body, and is non-toxic. The snout is flat and has 3 pairs of labial sockets. Body brown, with brown arrow-shaped spots on the back of the head, yellow on the back, covered with large irregular brown cloud-like spots, and white on the abdomen. A pair of degenerate claw-like stumps flank the cloaca.

The Burmese python is famous for its huge size, with an average length of 7 meters and a weight of 91 Kilogram. Burmese pythons grow in size due to their massive spine growth, and female Burmese pythons are larger than males.