The incidence of wild individuals of the yellow-margin box turtle is very rare, and only parasitic diseases and trauma caused by dogs are seen (because the yellow-edge box turtle has a special fragrance, some people in the Dabie Mountains use well-trained dogs to catch it) , There are occasional cases of infectious diseases in artificial breeding.

1. The parasitic disease turtle louse is adsorbed on the skin of the turtle's limbs, armpits and neck, directly sucking blood, affecting appetite and rest, resulting in weight loss and decreased resistance of the turtle . Therefore, medicated baths are required when stocking.

2. The tortoise with enteritis disease is slow to respond, loses appetite or does not eat, and the feces are soft and unformed in the initial stage, and in severe cases, diarrhea, the stool liquid is blood-colored and has a foul smell. The disease is caused by unpalatable food and drastic changes in temperature leading to digestive disorders. Scientific feeding and antibiotic treatment should be given as appropriate.

3. The cuticle of the plastron of the turtle with rotten nail disease fell off, and a few individuals were slightly inflamed and festered, mainly due to the long-term friction of the tortoise shell with the hardened cement pool bottom. For individuals with inflammation, 1% potassium permanganate solution or iodine can be used to scrub the ulcerated area, and the inflammation can be eliminated 2 to 3 times.