When the Florida red-bellied tortoise has rotten skin, if the symptoms are mild, it can be dry-raised for a period of time without drug treatment to keep the Florida red-bellied tortoise dry.

If symptoms are severe, medication may be required. It can be treated by applying drugs such as povidone-iodine or erythromycin, or it can be combined with drugs such as amoxicillin, but the course of treatment is relatively long and requires patience and careful treatment.