The shape is the most characteristic of the white antelope jackrabbit in its genus, a large hare species with a particularly large head and ears. Weight 2.7-4.73 kg, body length 553-670 mm, ears 162 mm long, mostly hairless, except for a fringe of white hair along the edges and tips. The sides of the body, including the limbs and buttocks, are black with white tips. The ventral surface, including the chin, throat, tail, and inside of the limbs, are all white haired. The upper part of the body is yellow or brown, with some black. Found in Mexico and the United States.

There is another feature of the white antelope jackrabbit There are many ways to deal with heat. The white antelope jackrabbit responds to seasonal changes by adjusting its body's metabolic rate. Compared to summer, the proportion of fur in winter has increased by 15%. The fur is highly reflective and insulating, helping to dissipate heat from the environment. The white antelope jackrabbit reduces blood flow to its large ears, which reduces heat exchange. In high temperature environments, high levels of thermal radiation can be tolerated when shelter cannot be found.