The lifespan of the American Fess lop is 5 to 12 years, and the American Fess lop is an adult in 4 months. It is not advisable to mate immediately at this time, which may easily cause premature birth and dystocia of the American Fess lop female .

It is therefore recommended to breed after 6 months of age. There is no fixed estrus time for American Fess lop rabbits, and they can be bred and reproduced all year round, but attention should be paid to avoiding high temperature and low temperature seasons to ensure the survival of the young.

The gestation period of the American Faith Lop is generally one month. The birthing time of American Fess lop rabbits is usually in the middle of the night or early morning, and the production will be completed in about ten to 30 minutes. The American Fess lop female rabbits who have just given birth can become pregnant, but it is best to avoid this situation. This can be very harmful to the body of the American Fess lop female, and it is best not to let the American Fess lop doe become pregnant more than twice in a year.