About 20 to 25 percent of eastern cottontail rabbits live to be 1 year old, and 85 percent of adult and young rabbits are killed by predators, including humans, each year. Other predators include hawks, owls, coyotes, wolves, ferrets and lynxes. Humans also use it for food; fur can also be used for clothing. On farms and gardens, Ben is seen as a vermin and is shot or trapped to protect plants. The average life expectancy of wild eastern cottontail rabbits is only 2 years, and the lifespan in captivity will be longer.

Eastern cottontail rabbits, also known as eastern cottontail rabbits , Florida cottontail rabbit, Eastern forest rabbit, distributed in the eastern and southwestern United States, southern Canada, eastern Mexico, Central and South America in the northernmost grasslands and shrubs. Grab grass, alfalfa, vegetables, and fruits in spring and summer, and bark, buds, twigs, maple, and dogwood in winter.