The lifespan of a Bryde's vole is approximately one year. As a Brinell's vole ages, its bones begin to slowly shrink and become thinner. To eliminate the possibility of diabetes, the appetite of Brinell voles will become worse when they are old, and their weight will drop significantly, then stabilize, and then decrease again when they are about to die.

With the aging of the body, the Brinell's vole's hair will become Gradually lose its luster, the older the hair becomes rougher, the more serious the hair loss. Until almost all the hair was lost, the Bryde's vole was about to die.